Background: The obese-asthma phenotype is not well defined. The aim of this study was to examine both\r\nmechanical and inflammatory influences, by comparing lung function with body composition and airway\r\ninflammation in overweight and obese asthma.\r\nMethods: Overweight and obese (BMI 28-40 kg/m2) adults with asthma (n = 44) completed lung function\r\nassessment and underwent full-body dual energy x-ray absorptiometry. Venous blood samples and induced\r\nsputum were analysed for inflammatory markers.\r\nResults: In females, android and thoracic fat tissue and total body lean tissue were inversely correlated with\r\nexpiratory reserve volume (ERV). Conversely in males, fat tissue was not correlated with lung function, however\r\nthere was a positive association between android and thoracic lean tissue and ERV. Lower body (gynoid and leg)\r\nlean tissue was positively associated with sputum %neutrophils in females, while leptin was positively associated\r\nwith android and thoracic fat tissue in males.\r\nConclusions: This study suggests that both body composition and inflammation independently affect lung\r\nfunction, with distinct differences between males and females. Lean tissue exacerbates the obese-asthma\r\nphenotype in females and the mechanism responsible for this finding warrants further investigation
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